AMPLITUDE is a Horizon 2020 European project bringing together partners from across Europe to develop multi-modal microscope and endoscope technologies that combine confocal and non-linear imaging techniques. Motivated by recent breakthroughs in multi-photon imaging, Amplitude aims to develop a system that exploits the optical properties of near-infrared (NIR), instead of visible or UV light, to image deep inside tissues.
The project will develop novel ultrafast lasers that access currently unavailable wavelengths, and use them for high-resolution non-linear imaging and confocal microscopy. Amplitude combines the deeper morphological and structural information provided by these modalities with functional/molecular information obtained by metabolic imaging and Raman spectroscopy, in a prototype multimodal microscope and endoscopic probe. The goal is to deliver imaging systems offering unparalleled label-free and real-time high-resolution imaging deep inside tissues.